The Gunners sold Alexis Sanchez to Manchester United in a swap deal which saw Henrikh Mkhitaryan go the other way and the Armenia international is set to make his debut at the Liberty Stadium.
Having been knocked out of the FA Cup almost a month ago, a rejuvenated Arsenal have a Carabao Cup final against Manchester City to look forward to, although they've won just three of their 12 away games in the league this season.
Wenger's side have lost to the likes of Nottingham Forest and Bournemouth in 2018 but will be confident of securing all three points against an improved Swansea side who still sit at the foot of the league table.
Danny Welbeck is unavailable due to a hip injury but Olivier Giroud returns from a hamstring problem amid reports that he could be on his way to Chelsea.
Mkhitaryan, meanwhile, is likely to feature in his first Arsenal game, with Wenger claiming that the 29-year-old's versatility is one of the Armenian's key strengths.
“I think Mkhitaryan can play in all positions in midfield,” Wenger said on Friday. “In a box-to-box role, certainly not a defensive role or as a holding player, but all the other positions are not out of reach.
“Until now he has played in a wide role but he can certainly absorb that role in a kind of winger or playmaker. I don’t rule it out for him to become a box-to-box player.”
Spanish midfielder Santi Cazorla remains a long-term absentee with an Achilles injury.
Arsenal have no players suspended for this game.
ARSENAL POTENTIAL STARTING LINE-UP
Wenger's interchanging between three and four defenders is likely to see the in-form Nacho Monreal continue in defence.
Jack Wilshere didn't train with the rest of the first-team squad on Friday but could still be involved, with Aaron Ramsey also available to start in central midfield alongside Granit Xhaka.
A front three of Mesut Ozil, Mkhitaryan and Alex Iwobi appears most likely, with Alexandre Lacazette expected to continue in his role upfront.
SWANSEA TEAM NEWS
Swansea have lost just one of their last seven games with Carlos Carvalhal in charge, winning seven points from his four league games in charge.
The Portuguese boss is without midfielder Renato Sanches for the match in Wales due to a hamstring injury but defender Federico Fernandez is available after missing the FA Cup tie with Notts County.
Carvalhal's side have the Premier League's worst home record this season, with three wins and 11 points from 12 games.
Jordan Ayew is the club's top scorer with seven goals to his name so far this season.
BEST OPTA MATCH FACTS
Swansea City have lost four of their last five Premier League meetings with Arsenal (W1), including losing each of the last three in a row.
Carlos Carvalhal will be the seventh different Swansea manager that Arsene Wenger has faced in the Premier League, in what is the 14th meeting. Indeed, since the start of the 2011-12 season, only against Sunderland (7) has Wenger faced as many different managers against a single opponent.
The Gunners have won four of their last five Premier League away games against the Swans, losing the other in November 2014 (1-2).
Arsenal have scored in all six of their away Premier League games against Swansea – only at West Brom (12) and Birmingham (7) do they have a better 100% record.
Arsenal have only lost one of their last 34 Premier League games against the side starting that day bottom of the table (W27 D6), losing 3-4 at Blackburn in September 2011.
The Gunners have won just three of their 12 Premier League away games this season. The last time they’d won as few on the road this far into a season was 2005-06, earning their fourth away win in their 15th game.
Danny Welbeck has had a hand in four goals in his last three Premier League starts against Swansea (three goals, one assist).
TV COVERAGE & KICK-OFF TIME
The match kicks off at 19:45 GMT on Tuesday, with no live television coverage available in the UK.