William Hill are anticipating more than £10 million to be wagered throughout the tournament, which finishes on July 7.
“There is a lot of hype around the Lionesses, with good reason, and our punters are putting their money where their mouths are,” said William Hill spokesman Joe Crilly.
“They are our worst result by far and at the moment they represent a six-figure liability. By the end of the tournament, that could be seven figures.”
The Three Lionesses lost in the semi-finals four years ago, with an injury time own goal by Laura Bassett against Japan ending their dream in Canada, and will be hoping to go deeper this time around.
England scored just nine goals in the 2015 edition, fewer than the other semi-finalists, and Neville will look to Ellen White and Jodie Taylor this time to ensure they are more potent in front of goal.
The 6/1 (7.0) favourite is USA’s Alex Morgan and she is best-backed to be the top scorer at William Hill. Morgan, who plays for Orlando Pride in the NWSL, has 101 international goals to her name in just 162 appearances.