The Reds surrendered the opportunity of a Wembley date at Anfield on Wednesday, crashing out of the League Cup at the semi-final stage 2-0 on aggregate.
They will want to progress in this tournament, but Klopp has a balancing act in terms of selection with a decisive league game against Chelsea lying in wait on Tuesday.
To that end, he has named a heavily altered first 11 with a strong bench to call upon if needed.
Nathaniel Clyne is not included in the matchday squad as he nurses an abdominal issue, while Adam Lallana is not included after sustaining a cut against the Saints that needed stitches.
Liverpool starting XI: Karius, Randall, Klavan, Gomez, Moreno, Lucas, Ejaria, Wijnaldum, Woodburn, Firmino, Origi
Liverpool bench: Mignolet, Milner, Stewart, Can, Wilson, Coutinho, Sturridge