The visitors are 11/2 (6.5) outsiders with dabblebet for the Championship title as Wolverhampton Wanderers continue their impressive campaign, but need a maximum of six wins from their final eight games to maintain their grip on the second automatic promotion spot.
Cardiff manager Neil Warnock now returns to Bramall Lane, where he spent eight years as a manager and won one promotion; fellow boyhood Blade Chris Wilder is hoping to emulate that achievement, with his side sitting just outside the play-off places.
A draw, which has occurred in three of the home sides' last four games, is 11/5 (3.2).
Their visitors meanwhile are an attractive 2/1 (3.0) to extend their winning run to a remarkable nine games.
Sheffield United goalkeeper Jamal Blackman begins a three-match suspension after his sending off against Brentford, so Simon Moore is expected to start against his old club; midfielder Paul Coutts remains sidelined with a long-term knee problem.
Cardiff will be without Jazz Richards and impressive midfielder Joe Ralls due to ankle and hamstring injuries respectively; ball-winner Aron Gunnarsson, though, made his first appearance in four months following a serious ankle problem by playing 23 minutes against Burton.
Bluebirds to be on song?
United have played 12 league games against teams above them this season and lost eight of them, with the two victories coming before October. While the Yorkshire outfit excel at sustaining pressure against the lesser sides, they perhaps lack pace in the type of games that necessitate counter-attacking.
By contrast, Cardiff have won six of their 12 encounters with top nine opposition, including a 2-0 victory over Monday’s opponents in the reverse fixture; an away win with Under 3.5 goals might appeal at 12/5 (3.4).
Preview and predictions
Sheffield United have failed to score in eight of their last 15 games in all competitions while Cardiff have kept 16 league clean sheets this term. That’s why for our best bet, we’re tipping a happy return to S2 for Warnock; and his side to be the only team to score at 10/3 (4.33). Essentially the same wager as the more popular "win to nil" market.