The Red Devils have traditionally struggled in Spain, recalling Sir Alex Ferguson’s loss to Athletic Bilbao in 2012, but Jose Mourinho did guide United past Celta Vigo to reach the Europa League final last year.
Manchester United are aiming to reach the quarter-finals for the first time in four years, while Sevilla haven’t progressed past the Round of 16 since 1958.
Interestingly, Manchester United have never played Sevilla in history, and so this will be a completely new fixture played in the Champions League.
The Premier League outfitters are backed at 7/5 (2.40) with dabblebet to win away from home, with Vincenzo Montella’s men the outsiders at 15/8 (2.88) to claim victory at their native Ramón Sánchez Pizjuán Stadium.
A draw, which appears unlikely given these two teams’ respective records home and away, is priced at 11/5 (3.20).
A huge boost for Mourinho comes in the shape of Eric Bailly and Marcos Rojo returning to the squad, as well as Paul Pogba coming back from illness.
Three hugely instrumental players for Manchester United should return and feature throughout the game, which is only going to aid them in search of away goals.
For Sevilla, Jesus Navas, formerly of Manchester City, has been featuring as right back throughout this season, which will be a main area Manchester United will likely aim to exploit.
Joaquín Correa picked up a nasty hamstring injury against Las Palmas last weekend and is expected to be ruled out, while forward Luis Muriel made a place on the bench after returning from injury and is likely to lead the line against the Red Devils.
Defensive discipline takes shape with Mourinho in Europe
Mourinho has a reputation of keeping things tight in the Champions League, and this fixture against Sevilla will be no different for him.
In this year’s competition, United have only conceded three goals in six games, two of those coming away from home.
With more defensive options at the Portuguese boss’ disposal, a clean sheet for Manchester United, currently priced at 7/4 (2.75), looks very favourable.
Preview and predictions
However, the best value for this mid-week encounter lies in two other markets.
With Romelu Lukaku back in red hot form, the best bet in this game is for the Belgian international to score at anytime at 13/10 (2.30). After all, he has scored four goals in six games in the Champions League this season.