For the first time ever their are five sides from the region of Madrid in the Spanish top flight, and the visit of Getafe to the Bernaebu on Sunday evening is the first of a number of derbies for Los Blancos this term.
Despite the defeat to Atletico, there were positives for Julen Lopetegui to take from the performance and the new manager will be hoping his side can record their tenth successive win against Getafe.
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Luka Modric started the midweek European clash on the bench following his late return from his summer holiday, but could be in line to start here.
Getafe will be without combative midfielder Markel Bergara, who picked up an injury this week.
Madrid's nine consecutive wins against Los Azulones have seen them score 35 goals in the process, and generally the trip to the north of the Spanish capital has been a tough fixture for Getafe.
Cristiano Ronaldo was particularly fond of scoring against Geta, netting 23 times against them, yet with the Portuguese forward gone Madrid will need goals from elsewhere.
The Europeans champions should still be too strong for Pepe Bordalas' men, but Real Madrid's opening games of the season are often low-scoring affairs.
Tips and predictions
Real Madrid to win and under 3.5 goals in the game is priced at 11/10 (2.10) and this looks like a solid option, given it has paid out in Madrid's opening league fixture in the last two seasons.
Prices correct at the time of writing. Please gamble responsibly.