Barcelona head into the penultimate round of matches in the group stages as the only side to have sealed their place in the last 16.
Nevertheless, the Catalans will want to ensure to spot in Group B and will do so with a win in Eindhoven against PSV.
Barca have won just two of their last nine away matches in the Champions League yet they are still clear favourites at 1/2 (1.50) with 888Sport. The hosts, meanwhile, have just one point from a possible 12 and are priced at 27/5 (6.40) with the draw offered at 15/4 (4.75).
Barcelona have a number of players missing through injury with striker Luis Suarez alongside midfielders Arthur, Rafinha and Sergi Roberto all ruled out. Philippe Coutinho looks likely to return from injury for the Spanish champions.
For PSV, Hirving Lozano returned from injury at the weekend in style with two goals and an assist and looks set to start on Wednesday night.
Barcelona's motivation for the game will be somewhat diminished given they have already qualified and while they still want to finish top, we are unlikely to see them at full throttle in Eindhoven.
With La Liga proving to be much more competitive than in recent years, the weekend game against Villarreal is possibly of more significance to the Blaugrana and while they were comfortable winners against PSV on matchday one, Wednesday's game could be more low-key.
Tips and predictions
Under 3.5 goals in the game is priced at 37/50 (1.74) and has paid out in seven of Barca's last eight away matches in the Champions League.
Also worthy of consideration is opposing goals at both ends, which is offered at an extremely healthy looking 29/20 (2.45). This has paid out in seven of Barca's last ten away Champions League games and was the correct selection when these sides met back on matchday one.