Sigi Schmid’s side have lost just once in nine MLS fixtures, and are currently enjoying a six-match unbeaten streak.
Having won three and lost none of their last five matches against this opposition, they are available at 16/5 (4.20) with bet365 to extend that record by coming out on top in Pennsylvania.
The U have lost four of their last six league fixtures, but can be backed at 4/5 (1.80) to secure a first victory over this opposition since 2012.
The last two encounters between the sides have both resulted in draws, and there are odds of 11/4 (3.75) available on this one also finishing up all square.
Ilsinho will miss out after going off injured against Chicago Fire last time out, joining Joshua Yaro on the sidelines.
Sebastian Lletget is a doubt with an ankle injury, while Rolf Feltscher remains out with a shoulder injury and Ashley Cole is suspended after being sent off against New England Revolution.
Galaxy’s recent run is even more impressive considering they were without Mexico internationals Giovani dos Santos and Jonathan dos Santos for a month due to the World Cup, with the brothers reminding everyone of their quality in two consecutive victories since returning.
The 3-2 win over an in-form New England Revolution last time out was achieved without star man Zlatan Ibrahimovic, who should be back to face Jim Curtin’s men.
With all of their big names back in action, the visitors will surely back themselves to extend their unbeaten streak to just under two months here.
Considering Philadelphia’s inconsistent recent run and lack of key creative hub Ilsinho, odds of 21/20 (2.05) seem generous on their poor record against this opposition continuing as they fail to win.