The newly promoted outfit are in high spirits after taking four points from their last two matches, although they have lost seven and won none of their previous 10 encounters against this opposition.
Indeed, the Cottagers have come away with nothing in each of the last five meetings and are hefty 18/1 (19.00) outsiders with William Hill to end that run with a victory here.
Pep Guardiola has overseen 29 wins and just two defeats in his 40 Premier League home games, and can be backed at 1/9 (1.11) to collect maximum points once again in this one.
Just one of the last 20 league matches at this ground have resulted in draws, but you can get odds of 8/1 (9.00) on this one finishing up all square.
Raheem Sterling is a doubt after sustaining a knock on international duty, while Danilo, Eliaquim Mangala, Kevin De Bruyne and Claudio Bravo are all ruled out.
Neeskens Kebano is sidelined with an ankle issue, with Tim Ream, Tom Cairney and Floyd Ayite all facing late fitness tests.
After earning a reputation for entertaining football during their promotion campaign, Slavisa Jokanovic’s team have certainly proved good value since returning to the top flight.
The play-off winners’ four league matches so far have provided 16 goals, more than any other team apart from London rivals Arsenal.
Having scored seven of those goals themselves in the three most recent matches, the Cottagers should fancy their chances of becoming the third fourth consecutive visiting team to get on target at the Etihad Stadium in the League.
Considering Manchester City have come out on top in each of those last three home games, odds of 11/8 (2.38) seem generous on them emerging victorious despite conceding against Fulham.