Diego Simeone’s men secured a comfortable 2-0 victory in the reverse fixture thanks to Koke and Antoine Griezmann’s first-half efforts.
Both sides have met three times previously and two of the meetings ended in stalemates which makes the price of (3.40) a tantalizing offer for the tie to go that way.
For Jorge Jesus' side, they will be heading into this match on the back of their 2-0 win over Pacos de Ferreira in Sunday’s Portuguese Primeira Liga outing which has helped them to move closer to the Champions League spot.
However, they face a herculean task to overturn their first-leg deficit, given their recent form in the competition which has seen them lose their last two duels. The betting firm has therefore tagged them as underdogs here at the odds of (4.80).
Atleti only need to avoid defeat to make it to the last four of the competition and having remained unbeaten in their previous three games, they are (1.16) to repeat the feat.
The Red-and-Whites have only managed to score five goals in their last four encounters and bookies offer (1.55) for less than two goals to surface here.