Ernesto Valverde's side are seven points clear at the top of the Primera Division and they come into the game brimming with confidence after a 6-1 win over Girona at the weekend.
They will hope to maintain that lead at the very least by beating the islanders, which would set them up nicely for their top-two meeting with Atleti this coming Sunday.
Las Palmas, meanwhile, find themselves in the relegation zone and face a tough task if they are to overcome a side that already defeated them 3-0 earlier in the season.
|Game||Las Palmas vs Barcelona|
|Date||Thursday March 1|
|Time||20:00 GMT / 15:00 ET|
|Stream (US only)||fubo TV (7-day free trial)|
TV Channel & Live Stream
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|beIN Sports||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on Sky Sports Football and it can also be streamed live online using Sky Go.
|UK TV channel||Online stream|
|Sky Sports Football||Sky Go|
Squads & Team News
|Goalkeepers||Ter Stegen, Cillessen|
|Defenders||Pique, Digne, Vidal, Umtiti, Vermaelen|
|Midfielders||Rakitic, Busquets, Iniesta, Coutinho, Paulinho, Roberto, Gomes|
|Forwards||Suarez, Messi, Dembele, Alcacer|
Valverde has named an 18-man squad for the match, which can be seen above. Full-backs Nelson Semedo and Jordi Alba have been ruled out through injury and suspension respectively, meaning there will be changes in defence. Paco Alcacer and Andre Gomes come into the squad.
Potential Barcelona starting XI: Ter Stegen; Vidal, Pique, Umtiti, Digne; Rakitic, Busquets, Coutinho; Suarez, Messi, Dembele.
|Position||Las Palmas players|
|Defenders||Simon, Aguirregaray, Garcia, Michel, Bigas, Galvez, Navarro, D. Castellano|
|Midfielders||Gomez, Etebo, Penalba, Halilovic, Momo, Gil, Samperio, J. Castellano, Aquilani, Gonzalez, Ramirez|
|Forwards||Calleri, Emenike, Ezekiel, Toledo, Tana, Exposito|
Las Palmas have a number of concerns ahead of the game, with Gabriel Penalba, Pedro Bigas, Momo and Emmanuel Emenike all carrying injuries.
Potential Las Palmas starting XI: Chichizola; Michel, Aguirregaray, Galvez, Navarro; Gomez, Halilovic, Etebo, Gil; Tana, Calleri.
Betting & Match Odds
Barcelona are favourites to win, with dabblebet offering odds of 2/11 on the Blaugrana. Las Palmas are deemed to be a 14/1 bet and a draw is more likely at 6/1.
Since losing to local rivals Espanyol in January, Barcelona have put together a 10-match unbeaten run and, having put six goals past Girona, they appear to have picked up the pace once more.
When they last faced off - at the Camp Nou in October - the game was played without spectators, which made for an eerie atmosphere, but did not stop Lionel Messi and Co. from winning.
Valverde will be expecting more of the same on Thursday and he will be hoping his key men come through unscathed with one eye on the upcoming match against Atleti.