During his pre-match press conference Mauricio Pochettino confirmed that Dele Alli and Hugo Lloris, as they were in the 2-1 weekend defeat to Liverpool.
On top of that, a "technical decision" means the Argentine will be without the services of both Toby Alderweireld and Kieran Trippier.
The money has certainly come for Inter as kick-off approaches, likely because of these absentees being confirmed.
On Monday morning the hosts were 2/1 (3.0) with bet365 but they’re now 13/8 (2.63) to start their campaign with three points. The Italians are competing in the Champions League for the first time in seven seasons, so it promises to be a special atmosphere at San Siro.
A worthy bet though, comes in one of the side markets due to the impact that Spurs' missing players will have on their starting line-up in Milan.
Serge Aurier looks set to deputise at right back and the former Paris Saint-Germain man is available at 3/1 (4.0) to be booked with bet365. Considering he will be attempting to contain the dynamic Ivan Perisic, it could be an extremely tough evening and disciplinary problems could well be on the agenda.
While his domestic record isn't all that eye-catching (two yellows and a red in 16 Premier League starts last season), the Ivory Coast international has rarely escaped the attention of referees in European competition since his arrival in north London.
Last term Aurier played six Champions League games and was booked in half of them. Tottenham could well be on the back foot for significant parts of the game and 3/1 (4.0) on Aurier to be booked with bet365 looks too big a price considering his match up against Perisic.
Odds correct at the time of publish.