The center-back resumed practice this week, having been in the treatment room since picking up an injury in a league tie against Freiburg on September 1.
"I'd like to think that the line-up will change," Nagelsmann said in his team news during a press conference on Friday.
"Steven Zuber and Nico Schulz are feeling better again, but both have a question mark over their heads.
"We'll have to see with Kevin Vogt, as to whether he trains again today.
"Havard Nordtveit and Adams are back in training but we do not want to take any risks with them.
"With Dennis Geiger, we are waiting for the day when he is free of any symptoms. He is scheduled to return to training next week."
He has made two league appearances in the German topflight so far.
The 23-year-old, who has been left out of Ghana's squad for the Africa Cup of Nations qualifying double-header against Sierra Leone later this month, was once on the books of Spanish side Real Mallorca and local club Medeama.