These sides were well matched last term with both league meetings ending up all square, but Maurizio Sarri's side are odds on across the board to come out on top this time around.
As usual, bookmakers are keen to offer punters incentives around such high-profile matches and we've looked at some of the concessions that are available.
bet365 - 2 Goals Ahead Early Payout Offer
Fancy either side to take a commanding lead at Stamford Bridge? bet365's offer will see pre-match single bets on the Match Result market settled as winners if the side in question takes a two-goal lead at any stage.
This offer applies to all games from the English Premier League, English Championship, English FA Cup, English EFL Cup, Spanish Primera Liga, Italian Serie A and German Bundesliga as well as Group Stage matches from the UEFA Champions League and UEFA Europa League up to and including Monday 31st December 2018. T&Cs apply.
William Hill - Enhanced odds and Scratch of the Day
Want a big price on the big game? Look no further than William Hill's enhanced odds section which has five selections available for this London derby.
Scratch of the Day is also available every Saturday and Sunday. Simply log into your William Hill account and match three symbols to claim a range of prizes including free bets, bet boosts and more. Each eligible customer can claim a reward each day so it's well worth checking out to see what you win. T&Cs apply.
SportPesa - Bonus token of up to £25 if the game ends 0-0
While goals aplenty are expected from this all London affair it's always good to know that a bore draw won't be a disappointment on the betting front.
That's where SportPesa come in. The online bookmaker are offering customers a bonus token worth up to £25 if the Chelsea v Arsenal game finishes 0-0.
The token will match the qualifying stake, up to £25 and qualifying bets must be placed pre-match on first/last/anytime goalscorer, correct score or half-time/full-time markets with a minimum price of Evens (2.0). T&Cs apply.