Zinedine Zidane's side solidified their position at the front of the market after back-to-back victories over their main rivals in the Spanish Super Cup, winning 5-1 over the two legs.
Since then though, it's been far from plain sailing for Los Blancos and a 2-1 defeat to newly promoted Girona on Sunday evening means they trail Barca by eight points already, an intimidatingly large gap even at this early stage of the competition.
What's more, Real Madrid have never won La Liga after trailing by eight or more points during the campaign, therefore dabblebet make them 14/5 (3.80) to buck that trend and reel in the league leaders over the course of the next few months though.
While Madrid are struggling to show the same form that saw them clinch the title with 93 points last term, Barcelona look every inch the champions in waiting.
A 2-0 win over Athletic Bilbao at San Mames was another potentially tricky tie negotiated for new boss Ernesto Valverde, who is now just 1/3 (1.33) to win the division having dropped just two points out of a possible 30 thus far.
Even without record signing Ousmane Dembele, who suffered a serious injury just four games into his Barcelona career, the squad have gone from strength to strength, having conceded just three times and notched 28 goals going forward.
Valencia have also made a fantastic start to the campaign and sit in second place, just four behind the Catalan giants after scoring just one goal fewer. That being said, they are not expected to maintain their early pace though and dabblebet price Marcelino García Toral’s side at 40/1 (41.0), making them fourth in the market.
Atletico Madrid were the last side to break the dominance of the "big two" in Spain back in 2014, and it's 25/1 (26.0) that Diego Simeone leads his side to another title but like their city rivals, Atleti are already eight points off the early pace.
dabblebet also have a market on which club will finish highest when Real Madrid and Barcelona are taken out of the equation. Los Rojiblancos are 8/15 (1.53) to win this contest again, something they've not failed to do since the 2011/12 campaign, and it is now 7/4 (2.75) that Valencia take that honour after their blistering start.