The Asturian revealed after Wednesday night's 6-1 win over Sporting Gijon that he will be departing once his contract is up at the end of the season - his third in charge at Camp Nou.
Aleix Vidal is sidelined for the remainder of the season after suffering a horrific ankle injury at Alaves last month.
Jeremy Mathieu is also out and will miss the game against Celta Vigo on Saturday night.
Apart from those two defenders, Barcelona boss Luis Enrique has an otherwise full-strength squad to choose from on Saturday.
However, Gerard Pique is just one yellow card away from picking up a one-match ban.
BARCELONA POTENTIAL STARTING LINE-UP
Barcelona boss Luis Enrique is set to keep faith with the 3-4-3 formation he has used over the last two games, but will also rotate his pack ahead of Wednesday's Champions League last-16 second leg against Paris Saint-Germain.
Lionel Messi is likely start in a free role against Celta Vigo on Saturday, with Andres Iniesta set to be kept in reserve and either Sergi Roberto or Rafinha used as a right forward.
Luis Enrique said on Friday that Celta are the only side to have beaten Barca by playing their natural, attacking game in his tenure and is wary of the club he coached before moving to Barca.
The Catalans face a tough task on Wednesday night after they lost 4-0 to Paris Saint-Germain in the sides' first meeting at the Parc des Princes last month.
CELTA TEAM NEWS
Celta Vigo are in 10th place in La Liga with 35 points, although the Galicians also have a game in hand after their match at home to Real Madrid last month was postponed due to storm damage at their Balaidos stadium.
Eduardo Berizzo's side seem safe enough in mid-table and with only an outside chance of making European competition through their league position, they may focus their attentions on the Europa League now.
Facundo Roncaglia is back from suspension, but Pablo Hernandez is doubtful for Saturday's game. Celta beat Barca 4-3 at home earlier on this season.
BEST OPTA MATCH FACTS
Barcelona have not lost any of their last 18 games in La Liga (winning 13 and drawing five), the best current run by any team in the Primera Division.
Celta Vigo have won more games against Barcelona under Luis Enrique than any other team (three in all competitions).
Lionel Messi has scored 36 goals in his 36 games for Barcelona this season in all competitions.
Marc-Andre ter Stegen has conceded eight goals against Celta Vigo in La Liga, at least five more than against any other side.
TV COVERAGE & KICK-OFF TIME
Barcelona versus Celta kicks off at 20:45 CET at Camp Nou on Saturday evening and will be shown live in the UK on Sky Sports 5 from 19:30 GMT.