This year, though, Diego Simeone's men are in a strong position to make sure they qualify for the last 16 and Los Rojiblancos will book their place in the knockout stages with a win over Monaco.
The Ligue 1 side have been in disastrous form this term and head to the Spanish capital second bottom of the French top flight, whilst they are also bottom of Group A after picking up just one point from a possible 12.
Atletico are extremely strong in their own stadium and SportPesa offer them at just 2/11 (1.18) for the win. Monaco meanwhile are priced at 16/1 (17.00) to win their first away game in the competition since April 2017, with the draw available at 6/1 (7.00).
Diego Costa is a doubt for the hosts after coming off at the weekend against Barcelona with a knock. Uruguayan centre-back pairing Diego Godin and Jose Maria Gimenez both missed the draw with the Catalans, although the latter has a chance of returning on Wednesday.
Monaco have endured a whole host of injury problems this season, although they were boosted by the return of Radamel Falcao at the weekend and the Colombian should be fit to face his former club.
There is little to make us oppose a home win, with Atletico clearly a superior outfit to a struggling Monaco.
The hosts won 2-1 in France back on matchday one and in the 13 matches they have played since then, they have suffered just one defeat. Atleti should win on Wednesday yet, most of their victories come in relatively low scoring games.
In 23 of the 26 matches they have won in their new stadium, fewer than four goals have been scored, with Atleti failing to score more than three goals in any of their last 18 matches in all competitions.
Tips and predictions
Atletico Madrid to win and under 3.5 goals is priced at 5/6 (1.83) and this selection has paid out in 88 per cent of Atleti's wins since moving to the Wanda Metropolitano just over a year ago.Atletico Madrid to win and under 3.5 goals at 5/6 (1.83) for a 3pt stake with SportPesa