The Danish outfit need to score at least four times at the Wanda Metropolitano on Thursday night and the last team to put four goals past Atletico in their own stadium in 90 minutes were Villarreal, way back in November 2007.
The likes of Antoine Griezmann and Diego Costa are likely to be given the night off, while Miguel Angel Moya should replace Jan Oblak in goal.
The visitors, meanwhile, continue to be without midfielder Aboubakar Keita and defender Erik Johansson.
Goals at a premium at Wanda Metropolitano
Atletico Madrid have played 18 matches in all competitions in their new stadium, with 12 of those games seeing under 2.5 goals.
The capital club are a defensive team even when they are at full strength, but with their most important attacking players likely to be rested, we should expect Los Rojiblancos to see out a low scoring game here.
Preview and predictions
The price of 21/20 (2.05) for fewer than three goals to be scored looks generous, especially given how many times it has paid out in Atleti's home games.
Furthermore, the context of the tie combined with Atletico's lead means we are much more likely to see the hosts defend their advantage than look to considerably add to it.