Arsene Wenger’s in-form Gunners team could go eight matches unbeaten with a victory over the Hornets in north London and will be confident of securing three points due to the return of several first team stars, while Walter Mazzari's men go into the game off the back of a FA Cup defeat to League One side Millwall.
Wenger made 10 changes for the FA Cup fourth round thrashing of Southampton on Saturday but players including Petr Cech, Mesut Ozil, Alexis Sanchez and Laurent Koscielny will all feature against Mazzari’s side.
Danny Welbeck, who scored twice at St Mary’s, is likely to be rested after only just returning from a knee injury while Wenger has selection dilemmas on his hands in attack with Lucas Perez, Alex Oxlade-Chamberlain and Theo Walcott all impressing during the 5-0 win.
Arsenal are blessed with an almost entirely injury-free squad for the game against Watford. It's a timely boost with their crucial Premier League clash with Chelsea at Stamford Bridge coming just four days later.
Francis Coquelin, Olivier Giroud and Laurent Koscielny are all expected to start against the Hornets after being rested at the weekend while Cech will replace David Ospina behind the sticks.
Bellerin tipped to become greatest
Wenger confirmed in his pre-match press conference that Mathieu Debuchy has returned to full training but could yet leave the club if an offer is received before the transfer window closes at 11pm on Tuesday.
Santi Cazorla is still expected to be out for the next six to eight weeks after undergoing surgery on a troublesome Achilles injury.
Granit Xhaka is serving the second of his four-game suspension.
Similarly, Arsenal boss Arsene Wenger will watch his second consecutive match from the stands after being charged by the FA following his misconduct towards the end of the Gunners' victory over Burnley.
ARSENAL POTENTIAL STARTING LINE-UP
Olivier Giroud will almost certainly return as the Gunners' main centre forward for the visit of Watford. The Frenchman has scored 11 goals in his last nine starts and looks likely to come in for Welbeck with Wenger being cautious over the England man's previous injury problems.
Mustafi targets unbeaten season
Talismanic duo Alexis Sanchez and Mesut Ozil are both fit and ready to play on Tuesday, while Nacho Monreal could come back in for Kieran Gibbs at left-back after the Spaniard didn't start against Southampton.
WATFORD TEAM NEWS
Watford haven't won in the league since a narrow victory over Everton in December, and their form has declined over the past month.
The FA Cup fourth round exit to Millwall may allow them to now focus on maintaining their status as top flight club, but they will find it tough against an Arsenal side who look imperious at home.
Mazzarri could start new forwards Mauro Zarate and M'Baye Niang after they completed their moves to Vicarage Road earlier in the week. Gunners boss Wenger admitted before the game that he once took the former AC Milan youngster on trial.
Premier League table
Troy Deeney and Etienne Capoue are their joint-top goalscorers with five goals each in the league.
BEST OPTA MATCH FACTS
- Arsenal have won their last seven league matches against Watford, netting 19 goals in the process (2.7 per game).
- Alexis Sanchez has scored in all three of his previous Premier League appearances against Watford and also has two assists versus the Hornets.
- Arsenal have conceded only four goals in their last seven Premier League home matches; all of which have been penalties.
- Heurelho Gomes has conceded 23 goals in eight Premier League games against Arsenal; nine more than he has versus any other opponent in the competition.
- Watford's record in their last 12 Premier League games to not be played on a weekend is W0 D2 L10. They haven't won a non-weekend Premier League game since April 2007 (4-2 v Portsmouth).
- Since Arsene Wenger took over at Arsenal in October 1996, the Gunners have been given more red cards in the Premier League than any other team (75).
TV COVERAGE & KICK-OFF TIME
Kick off is at 7:45pm on Tuesday 31st January but the match isn't being televised in the UK.