Dejan Lovren and Gaston Ramirez could be facing a lengthy spell on the sidelines after Mauricio Pochettino confirmed both players had been taken to hospital.
Southampton had been in control of their game against Sunderland at the Stadium of Light but threw away a two-goal lead despite dominating for large periods of the game.
A bad afternoon was then compounded as Ramirez went down under a challenge from Wes Brown before Lovren failed to get up from a challenge with Adam Johnson moments later, both having to be helped off the pitch with what looked to be serious injuries.
“They’re both being taken to hospital as we speak,” the Saints boss confirmed to reporters after the game.
“They’re being assessed at the moment so we don’t know exactly what’s happened. We hope that it’s not as bad as the images that we saw on the pitch.
“We may wait for them to return from hospital but if it’s a bit more serious then they will probably have to spend the night there.
“I would have to review the images on TV I don’t know exactly. From my point of view on the pitch it’s actually hard to see what happened.
“You could see that they were in a lot of pain. I saw them before going to hospital and both were in a lot of pain.”
The Argentinean coach admitted he was disappointed with the result, but praised his side for producing a "professional" display after what was a turbulent week for the South-coast side, after the departure of Chairman Nicola Cortese.
“We were able to dominate the oppositions and create many chances,” Pochettino added, “but I think overall in the future we need to work on our effectiveness, we need to be a lot ore clinical.
“I’m very happy with the performance today, they showed that they are great professionals that have the right attitude and I want to congratulate them as I have in the past.
“I think today all Southampton supporters should be very proud of their teams as they played very well in light of what happened this week."
Gus Poyet also spoke about the injury suffered by Ramirez and said he hoped there was no serious damage done to his fellow countryman, although he didn’t see anything wrong with Wes Brown’s challenge.
“I saw it clearly,” asserted Poyet to the media. “I feel sorry for Gaston because he’s a good friend of mine and I hope it’s nothing serious.
“It’s a typical challenge that you go, you commit, you touch the ball and in the follow through you get his ankle.
“If it was 15 years ago you would be talking about a proper English tackle, nowadays, you never know.”
The Sunderland boss went on to state that the result had to be seen as positive one, despite a dismal first half showing.
“[It’s a] very good point. I was talking to my assistant and we were saying it was looking really dark. It was looking like nothing was right for us.
“At that time if you’d have said to me you’d get a point from this game I would have taken it, for sure.
“I think it’s 10 games now [in which] we’ve lost one - not bad for a team at the bottom. The problem is people get carried away, when you win; they think you’re going to win the next and win the next.
“So we have a point, let’s be happy and we go into Wednesday with a different feeling.”