Chang has been on temporary leave at his family home in New York following the destruction caused by Hurricane Sandy in October, and will now not return to his role at the Premier League side.
A Reds spokesman told Sportingintelligence.com: "I can confirm Jen Chang has left Liverpool football club by mutual consent and has returned to the United States for family reasons.”
The former Sports Illustrated senior editor for football-related content joined the Merseyside outfit as the club's corporate and relations communications director in June 2012.
“Jen bought a fresh perspective to the overall communications function through the use of a variety of media channels, including social media and blogs," a statement provided to the Liverpool Echo continued.
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“We would like to thank Jen for his contribution to Liverpool Football Club during his time here and wish him well in his future career back in the US.
“Jen would like to thank everyone he has worked with during his time at Liverpool for their support and respect and wishes the club every success.”
The long-term Liverpool fan also formerly worked at ESPN and in the finance sector for investment banks and private equity firms.
Chang, who grew up in England, initially went to Queen Mary's University in London, before gaining graduate degrees from both Cambridge University and the London School of Economics.