It was the German topflight side’s first pre-season game, and they showed superiority at the Flutmulde Stadium, Gifford.
Daniel Didavi’s hat-trick, Landry Dimata and Osimhen’s brace plus Marvin Stefaniak’s effort handed Andries Jonker’s men a massive win.
The Nigeria international came off the bench to power in his side’s seventh goal of the game after ghosting past three defenders.
He capped a fine display with his second of the encounter after nodding in a cross from Gian-Luca Itter.
Wolfsburg meet Swiss second division side Rapperswil-Jona in their next pre-season game on Tuesday.