Berhalter has won all three of his games in charge, including a 1-0 victory over Ecuador on Friday in Orlando.
That win did come at a cost, though, with midfielder Weston McKennie suffering an ankle injury that looks set to keep him out for several weeks.
Chile, meanwhile, is looking to bounce back after losing 3-1 to Mexico in a friendly in San Diego on Friday night.
|Game||USMNT vs Chile|
|Date||Tuesday, March 25|
|Time||12:00am GMT / 8:00pm ET|
|Stream (US)||fubo TV (7-day free trial)|
TV Channel, Live Stream & How To Watch
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|Univision Deportes En Vivo||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game is not available for either broadcast or livestreaming.
|UK TV channel||Online stream|
Squads & Team News
|Goalkeepers||Johnson, Horvath, Jesse Gonzalez|
|Defenders||Yedlin, Omar Gonzalez, Brooks, Ream, Miazga, Long, Lima, Lovitz|
|Midfielders||Bradley, Pulisic, Trapp, Lletget, Roldan|
|Forwards||Zardes, Morris, Arriola, Ramirez, Baird, Lewis|
Gregg Berhalter has made seven changes to the side that defeated Ecuador.
McKennie is missing through injury, while Tyler Adams has returned to RB Leipzig. Ethan Horvath will come in at goalkeeper in place of Sean Johnson.
John Brooks and Aaron Long are rested, giving Matt Miazga and Omar Gonzalez a chance at center back.
DeAndre Yedlin, Michael Bradley, Corey Baird and Cristian Roldan are the other new starters.
USMNT starting XI: Horvath; Yedlin, Gonzalez, Miazga, Ream; Bradley; Baird, Roldan, Pulisic, Arriola; Zardes
|Goalkeepers||Arias, Cortes, Vigouroux|
|Defenders||Medel, Jara, Isla, Mena, Diaz, Maripan, Lichnovsky, Vegas, Opazo|
|Midfielders||Vidal, Aranguiz, Hernandez, Pulgar, Valdes, Martinez, Pavez, Meneses|
|Forwards||Castillo, Rubio, Mora, Morales|
Chile coach Reinaldo Rueda has made four changes from the side that lost to Mexico, with Oscar Opazo, Diego Valdes, Esteban Pavez and Gonzalo Jara coming into the team.
Chile starting XI: Arias; Isla, Jara, Maripan, Opazo; Medel, Valdes, Vidal, Pavez; Aranguiz, Castillo.
Betting & Match Odds
Chile are the slight favourites at 13/10 to prevail with bet365, while a draw is available at 23/10. A win for the USMNT is priced at 2/1.
Two teams who surprisingly missed out on the 2018 World Cup continue their rebuilds when they meet in Houston on Tuesday night.
Following an extended period under an interim boss, the USMNT has taken well to life under Gregg Berhalter, winning three from three while scoring six and conceding zero.
Berhalter's biggest test yet will come against Chile, who are still smarting from Friday night's 3-1 defeat to Mexico.
La Roja are being led by Reinaldo Rueda, but that may not last much longer if reports out of Chile are to be believed, with the manager under intense scrutiny ahead of this summer's Copa America.
Rueda took change in March 2018, but has only managed a 4-4-3 record while in charge of La Roja.
Chile are two-time defending champions of the Copa America, but Rueda may not be in charge this summer unless he can coax some improved performances out of his side.
The U.S. also has an important tournament coming up this summer, with the Gold Cup on the horizon.
Tuesday will be Berhalter's final chance to see his team in action before he names his Gold Cup roster, meaning it will be an important evening for several USMNT fringe players.
It will also be another test for Berhalter, who is looking to become the first USMNT manager to ever begin with four consecutive wins.