The Swedish front man was forced to sit out three games after being found guilty of violent conduct following an elbow on Bournemouth defender Tyrone Mings in the FA Premier League encounter on March 4. But he returns one month on and takes his usual spot up front.
Ander Herrera also comes back into the starting XI after being banned for two games for his sending-off in the FA Cup defeat to Chelsea, while Daley Blind is brought in at left-back to allow Antonio Valencia to be rested with Ashley Young switching flanks.
On the bench there are returns for Paul Pogba, 19 days on from suffering a hamstring injury against FC Rostov, and Luke Shaw, whose commitment was questioned at the weekend by manager Jose Mourinho. The England left-back has played just twice in four months for United.
Notably, there is no Wayne Rooney in the matchday 18 against his former club.
For Everton there is no return to Old Trafford for Morgan Schneiderlin three months on from his transfer from the Red Devils. He sits out the clash with a calf injury.
Manchester United: De Gea; Young, Bailly, Rojo, Blind; Carrick, Fellaini Herrera; Lingard, Rashford; Ibrahimovic. Subs: Romero, Pogba, Martial, Mkhitaryan, Shaw, Fosu-Mensah, Darmian.
Everton: Robles, Baines, A. Williams, Jagielka, Barkley, Lukaku, Mirallas, Gueye, Barry, Davies, Holgate. Subs: Stekelenburg, E. Valencia, Calvert-Lewin, Lookman, Pennington, Kenny, J. Williams.