With Zlatan Ibrahimovic and Wayne Rooney both rotated for the clash, manager Jose Mourinho has placed his faith in the young England international.
Ashley Young, meanwhile, starts at right-back while Sergio Romero lines up between the posts for a rare start for the Red Devils.
In all, Jose Mourinho has made seven changes from the side that beat Saint-Etienne on Thursday, with Paul Pogba and Juan Mata among those dropped to the bench.
In their places Michael Carrick and Henrikh Mkhitaryan return, with Anthony Martial retained following some fine recent form.
Luke Shaw has to make do with a place among the substitutes, however, with Matteo Darmian preferred at left-back.
Blackburn Rovers: Steele; Lenihan, Greer, Williams, Lowe; Conway, Feeney, Guthrie, Mulgrew, Emnes; Graham.
Manchester United: Romero; Young, Smalling, Rojo, Darmian; Carrick, Herrera; Lingard, Mkhitaryan, Martial; Rashford.