Lingard starts for only the second time in the last eight matches having netted in each of his previous Wembley appearances with United. The youngster scored the winner in last season's FA Cup final against Crystal Palace before striking early in the FA Community Shield win over Leicester City in August.
Martial returns having been rested for the trip to Saint-Etienne in midweek with Juan Mata reverting to the central attacking role behind lone striker Zlatan Ibrahimovic. That space has largely been filled by Henrikh Mkhitaryan in recent weeks but the Armenian was ruled out after limping out of the European win on Wednesday with a hamstring injury.
New signing Manolo Gabbiadini leads the line for Claude Puel's Saints having netted three goals in his previous two starts for the club. James Ward-Prowse, Nathan Redmond and the dangerous Dusan Tadic form the attacking midfield trio behind him as the south-coast club aim for their first major trophy since their 1-0 FA Cup win over United in 1976.
Manchester United starting XI: De Gea; Valencia, Bailly, Smalling, Rojo; Herrera, Pogba; Lingard, Mata, Martial; Ibrahimovic. Subs: Romero, Rooney, Carrick, Blind, Young, Rashford, Fellaini.
Southampton starting XI: Forster; Cedric, Yoshida, Stephens, Bertrand; Romeu, Davies; Ward-Prowse, Tadic, Redmond; Gabbiadini. Subs: Hassen, Long, Rodriguez, Caceres, Boufal, Hojbjerg, McQueen.