The Belgian defender is set to make just his third start of the season for Pep Guardiola's side, while Fabian Delph is also named in midfield instead of Raheem Sterling.
Sterling drops to the bench for City, who sit 11 points behind the leaders in fourth place.
Kurt Zouma starts for the Blues, while Victor Moses remains absent. Cesc Fabregas retains his place in Antonio Conte's starting XI.
Diego Costa also retains the faith of Antonio Conte as the Spain international starts up front in the hope of recovering his early season form.
Chelsea: Courtois; Zouma, David Luiz, Cahill (c); Azpilicueta, Kante, Fabregas, Alonso; Pedro, Diego Costa, Hazard.
Substitutes: Begovic, Ake, Terry, Matic, Loftus-Cheek, Willian, Batshuayi.
Manchester City: Caballero, Clichy, Stones, Kompany (c), Fernandinho, Delph, Sane, Silva, De Bruyne, Navas, Aguero.
Substitutes: Bravo, Zabaleta, Kolarov, Fernando, Toure, Sterling, Nolito.