The Portuguese forward was named in Zinedine Zidane’s starting XI for the meeting with Tottenham, edging him ever closer to another remarkable record.
Ronaldo remains 23 outings short of another Madrid icon, Iker Casillas, but still has time very much on his side.
He helped the Red Devils to two finals during his time at Old Trafford, emerging victorious in a penalty shootout over Chelsea in 2008.
A record-breaking transfer took him to Real Madrid in 2009, where he has gone on to collect another three European crowns.
Along the way, the 32-year-old has become the first man to net 100 goals in the competition – with his tally currently standing at 109.
Another run deep into this season’s event should help to carry him past Barcelona stalwart Xavi on the all-time appearance list.
He will then get the chance to pass Casillas at some stage in the future, providing another notable addition to an already glittering CV.