The Porcupine Warriors' four-game winless run has seen them drop to third on the table. With the change in technical staff, however, the Kumasi-based side will hope to pick an unlikely win when they play away to Wa All Stars on Sunday.
Two points and a place above Kotoko are Aduana Stars, who drew goalless with Wa All Stars in an outstanding game on Thursday. The 'Ogya' Boys are, nonetheless, tipped to claim full points when they host Tema Youth at Dormaa.
Surreal as it may be, Wafa are the current leaders of the championship, holding a point advantage. And when they host second-from-bottom Bolga All Stars in Sogakope, there will likely be an additional three points to consolidate their position.
The league's top two scorers are set to come up against each other when Ebusua Dwarfs play at home to Berekum Chelsea in Cape Coast. With seven goals for the former, Nicholas Gyan leads the goal king chart, while Chelsea's Stephen Sarfo sits just one strike below.
Frank Nuttall's Hearts of Oak, fifth on the log, hope to make it three wins in a row in their home clash with new boys Elmina Sharks.
After four successive draws, Liberty Professionals are favourites to beat confusion-stricken Great Olympics at the Carl Reindorf Park. The latter are currently in a state of turmoil following the appointment of Tom Strand as head coach.
Since Wednesday, the playing body has been divided into two factions, with one set training with Strand and the other with hitherto head coach Godwin Attram, who has been demoted to the deputy coach upon the Swede's arrival. According to Attram, he cannot work with the former Medeama trainer, and it remains to be seen which set turns out for Sunday's fixture.
And in Saturday's only game, 12th-placed Medeama will square off against sixth-positioned Bechem United.