The Reds, incredibly, have opened up a four-point gap at the top of the Premier League courtesy of their win at Wolves on Friday, and Manchester City's shock defeat to Crystal Palace on Saturday. Jurgen Klopp's men will be looking to maintain, or even extend, that advantage on Wednesday.
They welcome their former boss in Rafa Benitez, whose Newcastle side drew at home to Fulham on Saturday and sit 15th in the table. The Magpies have not won at Anfield since 1995, but Klopp will undoubtedly warn his players against complacency, with the stakes for every game as high as can be right now.
Here, Goal takes look at everything you need to know ahead of Wednesday's game...
Liverpool are set to be handed a double boost with both Trent Alexander-Arnold and Naby Keita passed fit for the game. Alexander-Arnold has missed the last two games with an ankle problem, while Keita suffered cuts to his foot and ribs against Wolves on Friday. Both will train as normal ahead of the game.
Joe Gomez (fractured leg) and Joel Matip (broken collarbone) are still out.
Rhian Brewster and Alex Oxlade-Chamberlain, meanwhile, are long-term absentees.
Liverpool do not have any suspended players for this game.
Liverpool Likely Line-Up
Klopp's ability to manage his resources has been a feature of Liverpool's success so far this season, so we can expect a degree of rotation here.
Nathaniel Clyne, one would suspect, will start at right-back while Alberto Moreno could be given a chance on the other flank as Liverpool seek to protect the brilliant Andy Robertson.
In midfield Gini Wijnaldum could return to the starting XI, while Adam Lallana will be eager for a start after a promising cameo appearance at Wolves.
Xherdan Shaqiri, an unused substitute at Molineux, may come into the forward line.
Newcastle team news
Benitez will make checks on the fitness of midfielder Jonjo Shelvey, who has been struggling with a thigh injury. Defenders Ciaran Clark and Florian Lejuene are likely to miss out, while Ki-Sung Yeung is away on international duty with South Korea.
Goalkeeper Karl Darlow is another doubt.
TV Channel & Kick-Off Time
The fixture will be not be broadcast live on the UK, as it is a 3pm kick off. Highlights can be found on Match of the Day, BBC One at 10.30pm.
In the United States, the game can be watched live on television on NBC Sports, kick-off 10am ET.
Best Opta Match Facts
Liverpool are unbeaten in their last 22 home games against Newcastle in all competitions (W18 D4), with their last such defeat coming in November 1995 in the League Cup (0-1).
Newcastle have won just two of their last 10 Premier League games against Liverpool (D4 L4), with both of those victories coming at St. James’ Park.
Since losing their first ever Premier League home game against Newcastle (0-2 in April 1994), Liverpool are unbeaten in each of the 22 such meetings since (W18 D4).
Liverpool haven’t lost a home league game on Boxing Day since 1986-87 (0-1 vs Manchester United), winning eight and drawing three since then.
Liverpool striker Daniel Sturridge has been directly involved in eight goals in his last nine games against Newcastle in the Premier League (seven goals and one assist).
Newcastle manager Rafael Benitez is winless in his three away games at Anfield against former club Liverpool (D2 L1), losing 0-2 in this fixture last season.