The 27-year-old struck past legendary Italian goalkeeper Gianluigi Buffon from the penalty spot to earn his side a 1-1 draw with PSG in Tuesday's Champions League Group C clash.
Juan Bernat's goal had put visiting PSG in front on the stroke of half-time, but a terrible touch at the back from Thiago Silva led to Jose Callejon being knocked down in the box as he pounced on the loose ball.
Insigne made absolutely no mistake from the spot, driving his penalty into the lower corner of the goal to pull his side level, making a small bit of history along the way.
5 – Lorenzo Insigne is the first Italian player in Champions League history to score in five successive home matches in the competition. Poacher. pic.twitter.com/HGueNr5auF— OptaJoe (@OptaJoe) November 6, 2018
Insigne has now scored five goals in his last six Champions League matches, having scored just four times in his previous 17 outings in the competition.
While the Italian may be scoring the goals, Slovakian team-mate Marek Hamsik set an impressive mark of his own in the contest.
The 31-year-old made his 512th appearance for the Italian side in all competitions, setting the record for the most in club history as he jumped past Giuseppe Bruscolotti.
Hamsik made his first competitive appearance for the club in August 2007, with Napoli having just gained promotion to Serie A.
The Italian club now sit second in Group C, despite being drawn with both PSG and Champions League runners-up Liverpool.
They are also within touching distance of Juventus in Serie A despite the red-hot league start for Cristiano Ronaldo and company, who remain unbeaten through 11 league matches.
Napoli return to Serie A action this weekend against Genoa ahead of the international break.
They'll make a return to Champions League action on November 25 with a match against a Red Star Belgrade side who pulled off a shock win over Liverpool on Tuesday.