The Pharaohs, who last participated in the tournament in 1990, were able to finish on top of Group E with 13 points, six points above Ghana to make it this time around.
Hector Cuper's men won all their games at home, picking four points in total against Ghana and only lost to Uganda in Kampala.
“It’s unfortunate we did not qualify for the World Cup. Every Ghanaian is disappointed we did not qualify,” Appiah told Happy FM.
“If we come together and access where the fault is, automatically we will be heading forward. Egypt for instance, had a plan [unlike Ghana].
"They had so many investors putting in some money in their qualifiers because they purposely wanted to qualify for the World Cup after being absent since 1990,” he added.
Appiah has been tasked by the Ghana FA to form a new team ahead of the 2019 Africa Cup of Nations, as the Black Stars seek to end a 35-year trophy drought in the competition.