The Premier League side have a three-goal advantage from the first leg after winning 4-1 in London last week and they will endeavour to finish the tie off without fuss.
Arsene Wenger's side are on a good run of form and extended their winning streak to six games by beating Southampton 3-2 three days after their continental exploits.
CSKA Moscow, on the other hand, were evidently deflated by their heavy defeat at the Emirates as they succumbed to a 2-1 loss at home to rivals Dinamo Moscow.
|Game||CSKA Moscow vs Arsenal|
|Date||Thursday, April 12|
|Time||20:05 BST / 15:05 ET|
|Stream (US only)||fubo TV (7-day free trial)|
TV Channel, Live Stream & How To Watch
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|Fox Sports 1||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on BT Sport 2 and it can be streamed live online using the BT Sport app.
|UK TV channel||Online stream|
|BT Sport 2||BT Sport app|
Squads & Team News
|Position||CSKA Moscow players|
|Goalkeepers||Pomazun, Akinfeev, Kyrnats|
|Defenders||Fernandes, Ignasevich, Vasin, A. Berezutski, V. Berezutski, Schennikov|
|Midfielders||Wernbloom, Milanov, Dzagoev, Vitinho, Golovin, Bistrovic, Natchko, Gordyushenko, Kosonov, Kuchaev|
|Forwards||Musa, Chalov, Zhamaletdinov|
Defender Kiril Nababkin missed the first game due to suspension but should be available for the home leg. However, Viktor Vasin is definitely out after suffering a season-ending knee injury.
Potential CSKA Moscow starting XI: Akinfeev; A. Berezutski, Ignasevich, V. Berezutski; Wernbloom, Nababkin, Kuchaev, Golovin, Natchko, Dzagoev; Musa.
|Goalkeepers||Ospina, Cech, Macey|
|Defenders||Mertesacker, Koscielny, Holding, Monreal, Mustafi, Chambers, Bellerin, Mavropanos, Kolasinac|
|Midfielders||Ramsey, Wilshere, Ozil, Iwobi, Cazorla, Xhaka, Maitland-Niles, Elneny, Nelson, Mkhitaryan|
|Forwards||Lacazette, Welbeck, Nketiah, Willock|
Pierre-Emerick Aubameyang is ineligible to play in the competition for Arsenal, meaning there will be changes in attack.
Other than that Wenger appears to have a full squad to choose from after resting a number of players at the weekend.
Potential Arsenal starting XI: Ospina; Mustafi, Koscielny, Monreal, Kolasinac, Bellerin; Xhaka, Ramsey, Ozil; Lacazette, Welbeck.
Betting & Match Odds
Arsenal are rated 5/4 to win the match according to dabblebet, who price CSKA Moscow at 15/8. A draw is available at 5/2.
With such a strong lead, the Gunners are 1/100 to reach the semi-finals and CSKA are given odds of 14/1.
Arsenal put in a strong performance in the first leg to establish a formidable lead over their Russian counterparts and Gunners fans will expect more of the same in Moscow.
They appear to have put their mid-season slump behind them, albeit much too late, but Wenger will be pleased with the likes of Alexandre Lacazette and Aaron Ramsey, who got the goals last Thursday, while Danny Welbeck delivered a man-of-the-match display over the weekend against Southampton.
It has become abundantly clear in the past few weeks, as a top-four finish becomes increasingly unlikely, that they need to win the Europa League if they are to rescue a disastrous campaign from total humiliation and that seems to have sharpened the focus of the north London men.
Indeed, having watched the mighty Barcelona fall to Roma in the Champions League quarter-final on Tuesday after boasting the same 4-1 lead, they are even more attuned to the fact that they cannot afford to take their eye off the prize on Thursday.
"The Europa League is important to us, everyone knows that. It is one of the big targets of the season now," Wenger told reporters ahead of the game. "I don't think we are under threat of complacency. We have a big job to do, but we are in a strong position. How we approach the game will be vital."