The Champions League's most successful club with seven titles, America routed Panamanian visitor Tauro 4-0 in Tuesday's quarterfinal first leg.
America cruised into the last eight after easing past Deportivo Saprissa 6-2 on aggregate and the Mexican giants were relentless again – Joe Corona, Henry Martin, Cecilio Dominguez and Andres Ibarguen all on target at the iconic Estadio Azteca.
The home side only needed 19 minutes to open the scoring, with U.S. international Corona firing a long-range strike into the top corner of the net.
America piled on the misery in the second half, scoring three unanswered goals against Tauro, which eliminated FC Dallas in the round of 16.
Martin doubled America's lead when he glanced a header past Oscar McFarlane in the 71st minute before Dominguez came off the bench and added a third with a curling effort eight minutes later.
Ibarguen completed the scoring nine minutes from the end as America head into next week's return leg poised to reach another semifinal.
Fellow Mexican outfit Tijuana struggled, however, following taking a 2-0 loss to the Red Bulls.
Tijuana faces an uphill battle to progress to the final four after succumbing to a Bradley Wright-Phillips brace at Estadio Caliente.
The Red Bulls, who will open their MLS campaign against the Portland Timbers on Saturday, hit the front foot in the ninth minute thanks to Wright-Phillips and the Englishman netted another priceless away goal with 23 minutes remaining.