Sanchez was expected to mount a strong start to the season for United, having not played for his country since March due to their failure to qualify for the World Cup.
Sanchez sat out Friday's 3-0 defeat to Peru in the United States due to visa issues but is available to face Mexico on Tuesday, and Rueda is keen for him to make a goalscoring impact with Chile having found the net just seven times since he took charge in January.
"I talked with him about that. What we want is that we hope his experience and ability can contribute to the team with his share of goals," said Rueda.
"And the important thing is that other players also score goals. The forwards have changed because they have not been in a good moment.
"Alexis is a benchmark, an elite player and he always enjoys being with the national team, joining his team-mates and getting to know the younger ones.
"We hope he has a good game because we know that he has also had difficulties with his club. He has not had the continuity that we all expected for one reason or another."
The winger has 39 total goals in 121 international caps with his most recent finish coming in a World Cup qualifier against Ecuador in October 2017.
Chile had no issues scoring against Mexico in the 2016 Copa America, where La Roja fired seven goals in an unforgettable quarterfinal beatdown of El Tri, with Sanchez scoring one of the seven.