Kampala Capital City Authority (KCCA) caused a major upset when they stunned Al Ahly on Tuesday afternoon.
The Ugandan champions recorded their first Group A win when they secured a 2-0 win over the Egyptian giants in an encounter which was played at the National Stadium in Kampala.
Al Ahly were presented with a glorious opportunity to break the deadlock 23 minutes into the game as they were awarded a penalty.
- What crisis?! Arteta’s blueprint emerges as vibrant Arsenal crush Spurs to ignite season
- Falcao making up for lost time at Rayo Vallecano as World Cup quest continues
- Gilberto Silva exclusive: Arsenal legend on Arteta, Edu, Partey's importance and beating Spurs
- Stop Lukaku, stop Chelsea? Tuchel needs big-money Blues attackers to help £98m star striker
However, Walid Soliman's effort from the penalty spot was easily saved by KCCA goalkeeper Charles Lukwago to ensure that the score remained 0-0.
The Red Devils continued to search for the opener with Phakamani Mhlambi's goal-bound shot blocked by the KCCA defence on the stroke of half-time.
The score was 0-0 at the interval following a first half which was dominated by Al Ahly.
The visitors introduced young forward Salah Mohsen, who replaced South Africa international Mahlambi a few minutes into the second half as the visitors looked to pile more pressure on KCCA.
However, it was the hosts who broke the deadlock through Ibrahim Saddam, who beat Al Ahly keeper Mohamed El Shenawy to make it 1-0 to KCCA in the 74th minute with Allan Okello grabbing the assist.
The Garbage Collectors then sealed their win over Al Ahly when Timothy Awanyi converted a late penalty in the 89th minute to make it 2-0.
As a result, Hossam El-Badry resigned from his position as Al Ahly head coach following a shocking defeat to the Caf Champions League group stage debuntants.
Elsehwere, Esperance de Tunis edged out Township Rollers in an entertaining encounter which played on Tuesday night.
The Tunisian champions registered their maiden win in Group A when they overcame Botswana giants 2-1 at the Stade Olympique de Rades in Rades.
Esperance broke the deadlock through Mohamed Belaili, who scored with a low shot to make it 1-0 to the hosts 26 minutes into the game.
However, Rollers pushed forward in numbers in search of the equalizing goal, and they were awarded a free-kick in a promising area after Joel Mogorosi was fouled.
Segolame Boy then stepped up and hit the back of the net from the resulting set-piece with Esperance goalkeeper Moez Ben Cherifia well-beaten in the 41st minute.
Esperance and Rollers were locked at 1-1 after the first 45 minutes.
A second half which was dominated by the Blood and Gold followed and they managed to restore their lead through Anice Badri.
The striker scored with a beautiful finish to make 2-1 to Esperance a minute into the second half after the Rollers defence was exposed and Badri punished them.
Rollers were struggling to contain the Esperance attackers and they were repeatedly denied by their keeper Mwampule Masule, who produced a series of great saves.
However, the bulky shot-stopper was beaten by Belil Mejri, who scored with a low shot with 11 minutes left on the clock.
The Blood and Gold were running rampant in the closing stages of the game and they sealed their 4-1 win deep into stoppage time when Badri grabbed his brace with a cool finish.
Tuesday's Group A results saw Esperance move to the summit of the group standings, while Rollers slipped down to second place, while KCCA and Al Ahly are placed third and fourth respectively on the table.