While the Eagles have been on the rise this season, newly-promoted Stuttgart are enduring a rather challenging time in the topflight.
Their predicaments led to the sacking of coach Hannes Wolf last month, something Boateng reckons could work in the favour of the thirteenth-placed side.
“It’s going to be a really difficult game," Boateng told his club's official website.
"The change in coach has given the whole Stuttgart team a boost.
"VfB are playing good football at the moment, but we know what we’re capable of and want to pick up another three points.
"I’m confident we’ll do just that - we’re as well prepared as ever.”
“I definitely would’ve liked to be involved, but the team will manage fine without me.
"I trust the boys to return home with a good result.”
Eyes set on playing in Europe again next season, Frankfurt currently sit third on the league log.
Only one point separates the Eagles from second-placed Borussia Dortmund, leaving the door open for Niko Kovac's men to move up by one place by the end of this weekend's matchday 24 action.
On a personal note, Boateng has made 23 Bundesliga appearances, involving 20 starts and five goals, for Frankfurt so far this campaign.
He joined the Eagles last summer.