David Ospina replaces Petr Cech in goal, with Mathieu Debuchy, Per Mertesacker and Rob Holding in defence.
Calum Chambers, Mohamed Elneny and Francis Coquelin are join in midfield by Jack Wilshere and Ashley Maitland-Niles.
Arsenal are already guaranteed their place in the knock-out stage of the competition and can secure top spot by avoiding defeat in Germany.
Arsenal XI: Ospina; Mertesacker, Debuchy, Holding; Chambers, Elneny, Coquelin, Wilshere, Maitland-Niles; Welbeck, Giroud.
Substitutes: Macey, Sheaf, Willock, Nelson, Iwobi, Nketiah, Akpom.
Cologne XI: T. Horn; Mere, Maroh, Sorensen; Klunter, J. Horn, Jojic, Ozcan; Guirassy, Osako, Cordoba.
Substitutes: Kessler, Olkowski, Risa, Lehmann, Rausch, Nartey, Bissek.