Letsoalo came into this campaign brimming with confidence having played an instrumental role in helping South Africa clinch the 2021 Cosafa Cup and he was able to carry his scoring form to Royal. The man also better known by his middle name Sepana hit the ground running in the new season - scoring in five successive matches in the PSL between September and October last year including a brace as Thwihli Thwahla embarrassed Kaizer Chiefs by claiming a 4-1 win. However, Sepana endured a five-match goal drought in the league in November 2021, while also failing to score for Bafana in their 2022 Fifa World Cup qualifying campaign despite making five appearances in the qualifiers. However, the lethal marksman rediscovered his scoring form towards the end of the year - scoring three goals in his last four league matches of 2021.
Sepana began the year 2022 by turning out for an Amabutho side which lost their two matches in the PSL mid-season tournament, DStv Compact without scoring. However, the Royal penalty specialist was the only player who was able to come near Mamelodi Sundowns' goalscoring machine Peter Shalulile in the race for the PSL Golden Boot award. Letsoalo continued to score goals for Thwihli Thwahla after the turn of the year and he hit form in April - propelling the team to the Nedbank Cup semi-finals by scoring five goals in three matches - including a brace against the University of Pretoria in the quarter-finals, but he was unable to help Royal avoid a defeat to Sundowns in the semi-finals. Sepana wrapped up his campaign with a goal in their 3-2 defeat to Sundowns in the league clash on May 23.
The gifted marksman ended the season with 17 goals from 31 matches across all competitions for Royal including two in the Nedbank Cup. The Ga-Molepo-born player was the highest-scoring South African player in the PSL with only PSL Footballer of the Year Shalulile netting more goals than him in the elite league. However, Letsoalo was dropped from the Bafana squad ahead of their 2023 Afcon qualifier against Morocco wIth national team head coach Hugo Broos stating that it is because Sepana's 'main contribution' in terms of goals during the season come from the penalty spot. Seven of the 17 goals that Letsoalo scored were from the penalty spot.