Spurs sit a place and four points above Arsenal coming into the match and a victory for Mauricio Pochettino's men would put a real gap between them and their rivals.
The Gunners, though, will be desperate to prevent that and keep up with the top four, meaning the derby is perfectly set up.
dabblebet offer Spurs at 21/20 (2.05), while Arsenal are priced at 12/5 (3.40) and the draw is available at 14/5 (3.80). The online bookmaker is also offering "2 Up", where a pre-match single on either team to win will be paid out as a winner if their chosen side goes two goals up. T&Cs apply.
Arsenal goalkeeper Petr Cech could be fit for the game as the calf problem he picked up last weekend is not as serious as first thought. Nacho Monreal and Danny Welbeck should also be available.
For Spurs, Toby Aldeweireld played his first game since October in the FA Cup in midweek and should return to the heart of defence.
Visitors poor on the road, hosts strong at home
Arsenal have won just three of their 13 away matches in the Premier League this term, and have also been goal-shy on the road with just 15 strikes to their name, so they will be hoping new signing Pierre-Emerick Aubameyang will help change that.
Spurs, for their part, have the second best home defensive record in the league conceding just nine times.
Pochettino's men are also unbeaten at Wembley since the opening day of the season and were hugely impressive in their 2-0 win over Manchester United last week.
Tips and predictions
2-3 goals in the game is offered at 23/20 (2.15) and seems a good angle to take in backing a relatively tight game.
Both sides can score although it should not be particularly high scoring encounter, and this selection has paid out in seven of the last eight north London derbies.