Southampton did them a favour by holding Liverpool to a 0-0 draw at the weekend but they will now have to see them off to keep up the pressure on the current top four.
|Game||Southampton vs Arsenal|
|Date||Wednesday, May 10, 2017|
|Time||19:45 GMT, 14:45 ET|
TV CHANNEL & LIVE STREAM
In the UK, the match will not be available to watch live on television.
|UK TV channel||Online stream|
In the US, the match will be available to watch live on television on NBCSN and by stream via NBC Sports Live.
|US TV channel||Online stream|
|NBCSN||NBC Sports Live|
SQUADS & TEAM NEWS
|Goalkeepers||Forster, Taylor, Hassen|
|Defenders||Cedric, Yoshida, Gardos, Martina, Pied, Stephens, Bertrand, Caceres|
|Midfielders||Clasie, David, Tadic, Romeu, Ward-Prowse, Reed, Redmond, Hojbjerg, Boufal, Isgrove, Hesketh, McQueen, Sims|
|Forwards||Long, Rodriguez, Austin, Gabbiadini|
Matt Targett, Virgil van Dijk and Alex McCarthy are out for Southampton, while Charlie Austin is continuing to build up his fitness and is likely to feature for the Under-23s before returning to the first team.
|Goalkeepers||Ospina, Cech, Martinez|
|Defenders||Debuchy, Gibbs, Mertesacker, Gabriel, Koscielny, Monreal, Bellerin, Jenkinson, Holding, Mustafi|
|Midfielders||Ozil, Oxlade-Chamberlain, Ramsey, Coquelin, Elneny, Iwobi, Xhaka, Maitland-Niles|
|Forwards||Giroud, Walcott, Alexis, Welbeck, Perez|
Granit Xhaka is a doubt for Arsenal due to a recurrence of an ankle injury, so Francis Coquelin could come into the midfield.
Jeff Reine-Adelaide and Santi Cazorla are definitely out and Lucas Perez is likely to miss out again having suffered a minor setback in training ahead of the match against United.
BETTING & GAME ODDS
Arsenal are 11/10 favourites to win away from home, according to Oddschecker, with Southampton priced at 11/4 and the draw available at the same odds.
Alexis Sanchez is the 9/2 favourite to score first, with Olivier Giroud rated at 5/1 and Danny Welbeck 11/2. Manolo Gabbiadini is the top choice for the hosts at 6/1.
A few days after giving Arsenal hope in the race for Champions League qualification, Southampton will attempt to take it away again on Wednesday night.
It should be noted that the Saints' 0-0 draw at Liverpool - and strong form against the Reds throughout the 2016-17 campaign - was not particularly reflective of consistently good performances against the Premier League's top sides, but there is one other top-six team they have repeatedly troubled this term.
That happens to be Arsenal, who needed a 94th-minute Santi Cazorla penalty to defeat them in September and were then knocked out of the EFL Cup by Claude Puel's team at the end of November.
It really depends on what version of Southampton's defence turns up; they have kept back-to-back clean sheets in their past two games but having sold Jose Fonte to West Ham and lost Virgil van Dijk to injury, there has been both promising signs and inconsistency in the partnership between Jack Stephens and Maya Yoshida.
Arsenal have looked a better team since switching to a 3-4-3 formation that caused the Saints problems when they faced Chelsea. Though stained by defeat in the north London derby, the new system has brought out the best in Aaron Ramsey and accommodates both Mesut Ozil and Alexis Sanchez in central positions.
They have stumbled across it at the right time, because the Gunners will need to be near perfect to reel in either Liverpool or Manchester City to keep their place in Europe's top competition.