Zinedine Zidane's side made it six games without defeat by beating Malaga 2-1 at the weekend and they are eager to beat city rivals Atletico, who are four points ahead, to second place.
The visitors, meanwhile, are on a disappointing run, with just one win from their last five games in all competitions, so they face a difficult task in the Spanish capital.
|Game||Real Madrid vs Athletic Bilbao|
|Date||Wednesday, April 18|
|Time||20:30 BST / 15:30 ET|
|Stream (US only)||fubo TV (7-day free trial)|
TV Channel & Live Stream
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV, as well as on a web browser.
|US TV channel||Online stream|
|beIN Sports||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on Sky Sports Football and it can be streamed live online using Sky Go.
|UK TV channel||Online stream|
|Sky Sports Football||Sky Go|
Squads & Team News
|Position||Real Madrid players|
|Goalkeepers||Navas, Casilla, Luca|
|Defenders||Carvajal, Ramos, Vallejo, Theo, Marcelo, Varane|
|Midfielders||Isco, Asensio, Casemiro, Kovacic, Kroos, Modric, Vazquez|
|Forwards||Bale, Benzema, Ronaldo|
Defender Nacho is the only injury concern for Los Blancos and Zidane has a fully-fit panel to choose from otherwise. The 19-man squad announced by Madrid can be seen above.
Potential Real Madrid starting XI: Navas; Carvajal, Ramos, Varane, Marcelo; Casemiro, Kroos, Modric, Isco; Ronaldo, Bale.
|Position||Athletic Bilbao players|
|Goalkeepers||Kepa, Iago, Simon|
|Defenders||Saborit, I. Martinez, Alvarez, Nunez, Lekue, De Marcos, Etxeita, Balenziaga, A. Lopez|
|Midfielders||San Jose, Benat, Iturraspe, Susaeta, Rico, Vesga, Raul Garcia, Cordoba, Gil, Nolaskoain, Munoz|
|Forwards||Sola, Muniain, Williams, Merino, Aduriz|
Athletic will be without the services of defender Xabier Etxeita, but Jose Angel Ziganda has no other personnel issues to contend with.
Potential Athletic Bilbao starting XI: Kepa; Balenziaga, Alvarez, De Marcos, I. Martinez; San Jose, Benat, Susaeta, Raul Garcia, Cordoba; Williams.
Betting & Match Odds
Real Madrid are favourites to win at odds of 1/5, with Athletic's chances rated 12/1. A draw between the teams is a 13/2 bet.
Real Madrid have a crunch Champions League clash against Bayern Munich to look forward to next week but, for now, their focus is very much on beating Athletic Club in order to continue their bid to claim second place in La Liga.
Los Blancos defeated Malaga in their last outing without the likes of Cristiano Ronaldo and Gareth Bale, but both players are likely to return to the starting XI for the game against Los Leones, who managed to draw 0-0 when the sides met at San Mames earlier this season.
"They’re a team that don’t deserve to be where they are in the table," Zidane told reporters ahead of the game. "Maybe more was expected this year because they’re a very good team that competes very well. They’re a complete team that will come here to try to pick up points.
"The most important thing for us is to try to get back to second place, which is our goal. We climbed back up to third, tomorrow we’re playing at home and we want to get closer to second place and we’ll try to put in a good performance."
Madrid will have a week to prepare for the game against Bayern in Bavaria next week, but they can kick things off early with a strong display at home on Wednesday.