Last week's 3-0 first leg win means that there is little danger of Real Madrid suffering any kind of cup upset on Wednesday night at the Bernabeu.
That is just as well for Los Blancos, given the difficult position they find themselves in La Liga, and the 16 point gap to leaders Barcelona means that realistically the Copa Del Rey has become the best chance for Madrid to finish the season with any domestic silverware.
Their opponents Numancia are more concerned with their promotion push from the Segunda Division and as manager Jagoba Arrasate rested players for last week's first leg, he is likely to make even more changes to his starting eleven with the side trailing by three goals.
Despite not being in great shape, Madrid should be able to record a routine win and Betfair offer a home win at 1/9 (1.11) while Numancia are priced at 25/1 (26.00) and the draw can be backed at 5/1 (6.00).
Expect opportunities for some members of the Real Madrid youth academy, while the likes of Marcos Llorente, Dani Ceballos and Kiko Casilla all look set to start for Real Madrid.
Gareth Bale played 60 minutes of the first leg and 80 minutes on Sunday in La Liga, so Zinedine Zidane may consider resting him now for the weekend game against Villarreal.
Numancia are also likely to field a weakened eleven, with the visitors having Pape Diamanka suspended after his sending off in the first leg.
Los Blancos to strike early
In recent matches, Real Madrid have been making positive starts yet failing to really capitalise on their strong early showings, but against Numancia it should be more straight-forward for them to take advantage of the chances created and backing them to lead early on looks like an intelligent angle to invest in the hosts.
Tips and predictions
Madrid are offered at 11/10 (2.10) to score the first goal of the game before 20 minutes, while the European champions are also offered at 4/5 (1.80) to be ahead at the half hour mark which seems like an extremely solid bet for this game.Real Madrid to be leading at 30 minutes at 4/5 (1.80) for a 3pt stake with Betfair