Los Blancos beat Bayern 2-1 in the sides' first match at the Allianz Arena on Wednesday and, with Barcelona set to clinch the Primera Division title, European glory is very much the focus for Real.
Madrid are currently third in La Liga, 15 points behind Barca, with five fixtures remaining. And, although they cannot catch the Catalans, they will want to finish above Atletico, who are four points ahead with one more match played, in second spot.
With rotations planned ahead of the Bayern game, Goal takes a look here at everything you need to know ahead Saturday's match against Leganes...
Real Madrid injuries
Isco and Dani Carvajal picked up injuries against Bayern on Wednesday and both players will be absent this weekend. The two will also miss the second-leg match at home to the German side on Tuesday. Meanwhile, Nacho is doubtful after his recent injury.
Real Madrid suspensions
Real Madrid have no players suspended for the game against Leganes.
Real Madrid potential starting line-up
Cristiano Ronaldo will be rested, so Gareth Bale is set to return to the starting line-up after he was left out of the team to play Bayern Munich on Wednesday, the Welshman failing to make it on for a single minute at the Allianz Arena.
Karim Benzema, who was used as a substitute in Germany, will also start, with Marco Asensio likely to feature from the outset after his match-winning performance from the bench in midweek.
In midfield, Marcos Llorente, Mateo Kovacic and Dani Ceballos could all come in to allow Casemiro, Luka Modric and Toni Kroos a rest.
Raphael Varane is likely to be rested as well, with Jesus Vallejo set to start in his place, while Theo Hernandez will deputise for Marcelo and Achraf Hakimi should come in for the injured Carvajal.
Leganes Club team news
Leganes knocked Real Madrid out of the Copa del Rey earlier this season with a shock 2-1 win at the Bernabeu and the capital club are safe from relegation with 40 points from their 34 matches in La Liga this term.
The 'Pepineros' drew 0-0 with Deportivo La Coruna last weekend, a result that confirms their status in the top flight for next season. However, they have lost their last six league games away from home.
Winger Alexander Szymanowski is sidelined, while defender Ezequiel Munoz is doubtful.
TV channel & kick-off time
Real Madrid versus Leganes kicks off at 18:30 local time on Saturday and will be shown live in the United Kingdom (UK) on Sky Sports Football (via the red button) and also on Sky Sports Mix from 17:25 GMT.
In the United States (US), the match is live on beIN Sports and kicks off at 10:30 ET.
Best Opta match facts
Real Madrid have won each of their three league games against Leganes, scoring at least three goals in each of those encounters.
Los Blancos have not lost any of their last seven league games (won five, drawn two) and they could go unbeaten in eight in a row for the first time this season.
Leganes have failed to win in their last 13 La Liga away games (drawn three, lost 10), failing to score in eight of them.
Leganes are the only team that Cristiano Ronaldo has failed to score against in his La Liga career.
Karim Benzema has scored only two goals in his last 10 La Liga games, both from the penalty spot, the only two penalties he has taken for Real Madrid in the competition.