Quique Setien's side have slipped down the table after a run of just three wins in 10 matches and their European hopes are threatening to disintegrate.
The visitors meanwhile are one of the in-form sides in the division, winning five of their last seven La Liga clashes and Marcelino's men are pushing for a Champions League spot.
This fixture last season produced one of the best games of the 2017-18 campaign with Los Che triumphing 6-3 in a thrilling encounter.
These two sides also met in the semi-final of this season's Copa Del Rey with Valencia's winning 3-2 on aggregate after a 2-2 draw in Seville. Betis can be backed at 19/10 (2.90) with William Hill, with Valencia on offer at 29/20 (2.45) and the draw at 12/5 (3.40) .
Valencia striker Rodrigo Moreno has missed the last two games, but the club are optimistic he will back on Sunday.
However, full-back Cristiano Piccini and midfielder Geoffrey Kondogbia are definitely out for the visitors. Betis meanwhile are likely to be without injured midfielder William Carvalho.
One of Betis' main problems this season has been converting their enormous amounts of possession into goals scored.
Only Barcelona average more possession per game than Los Verdiblancos, yet nine teams have scored more goals. Nevertheless at home Setien's side have managed to score in 14 of their 16 games this term, including each of their last 10.
Valencia for their part have picked up their scoring rhythm in recent weeks, netting in seven of their last eight away games and in the only game they drew a blank during that run at Rayo Vallecano they missed a penalty and created plenty of chances.
Tips and predictions
Both teams to score is priced at 7/10 (1.70) and this selection has comfortably paid out in the last two meetings between these sides in Seville.
Both teams to score and over 2.5 goals is offered at 11/10 (2.10) and this has proved the winning bet in seven of Betis' last 10 home games in all competitions.