The Magpies face a fight to preserve their place in the top tier, having failed to win any of their last eight league matches at St James' Park.
As such, Rafael Benitez and his players will be acutely aware that a drastic improvement in home form could well prove pivotal if they are to achieve that ambition.
Newcastle have won just three Premier League fixtures on their own patch so far this season and dabblebet offer 5/1 (6.0) that make that four this weekend.
The last three Premier League matches at St James' Park have ended all square and dabblebet offer 3/1 (4.0) that Benitez's charges settle for a share of the spoils.
Rafael Benitez will hope that Islam Slimani is fit to make his debut after his loan move from Leicester, whilst Joselu may return after illness.
Phil Jones could return for the visitors, but Marouane Fellaini remains out with a knee problem.
Newcastle have scored just four goals in their last eight league matches at St James' Park, failing to find the net in five of those fixtures.
Joselu is the Magpies' top scorer in the league thus far this season with just four goals.
Given those struggles in front of goal, it is little surprise that dabblebet offer 4/5 (1.80) that there are fewer than three goals in this game - the selection would have landed in eight of the last 10 league matches on Tyneside.
Tips and predictions
Manchester United have kept a clean sheet in seven of their last eight matches, winning six of them.
dabblebet's 7/5 (2.40) quote, therefore, for the visitors to win to nil could well prove popular with punters ahead of Sunday's showdown.