After winning 16 and losing just one of 19 league matches in the first half of the campaign, Les Parisiens are nine points clear at the top as the season resumes.
Having won each of the last 12 encounters between the sides, they are clear 1/4 (1.25) favourites with dabblebet to maintain their winning streak in this one.
However, Claudio Ranieri's men have won six of their last seven league matches at home, and are on offer at 11/1 (12.00) to upset their opponents by beating them for the first time since 2004.
None of the guests' last 15 fixtures have resulted in a draw, but there are odds of 5/1 (6.00) available on them dropping two points here.
Watch and bet on Nantes v PSG
Prejuce Nakoulma is still a doubt for the hosts after not playing in the cup, although Ciprian Tatarusanu and Adrien Thomasson should return to the team.
Thiago Motta and Layvin Kurzawa are hoping to shake off injuries for the visitors, although Edinson Cavani may still not be included following his late return from the winter break.
Attacks to lead the way
Realistically, the likes of Neymar and Kylian Mbappe would surely be enough to lead Unai Emery's team to victory regardless of whether Cavani returns to the fold, having scored eight goals in two cup games without their top scorer in the last week.
However, the Spanish manager may have more problems at the other end of the pitch, where his defence has only kept two clean sheets in the last 12 fixtures in all competitions.
Having failed to score just once in their previous 19 matches, a home team spearheaded by the in-form Emiliano Sala will certainly fancy their chances of earning some long-awaited joy against this opposition.
Tips and predictions
Indeed, odds of 21/20 (2.05) certainly seem generous on Nantes joining PSG on the scoresheet, in a bet that would have paid out in 10 of the champions' last 12 games.