The Blaugrana saw off Eibar 2-0 on Saturday to maintain their lead seven point lead atop the Primera Division standings.
This fixture has served up some memorable moments in the past and Barca are offered at (2.15) to bag the essential away victory.
A draw in West London is priced at (3.60).
This will be the 13th time that these two giants will face each other, making it the fifth most played fixture in the Champions League.
The Blaugrana however hold the advantage in the knockout stage eliminating the Blues on three occasions. Backing them to either win or draw at Stamford Bridge is available at odds of (1.30).
Ernesto Valverde’s charges have the best defensive record in the Champions League this season, conceding just once. However they have never kept a clean sheet in West London and are valued at (1.35) to concede again while it’s (1.65) for both teams to find the back of the net.
Lionel Messi has played 655 minutes against Chelsea in the Champions League but is yet to score. This makes Conte’s men the team he has featured for that many minutes and not net.