Vela, who has not played much for Real Sociedad after agreeing to a move to MLS expansion side LAFC for next season, was selected over his future MLS rival Giovani dos Santos. Meanwhile, Lozano, who is off to a hot start to life in the Eredivsie gets a look on the other wing.
The lineup likely will see Mexico manager Osorio utilize two defensive midfielders - something he has been reluctant to do since taking over El Tri in November of 2015. But after running into trouble controlling the midfield against top teams like Germany in previous encounters, the manager appears set to make a change.
The lineup could, however see Reyes line up as a third center back with Herrera in front of him. Either way, Mexico will have its hands full with Premier League stars Kevin De Bruyne, Eden Hazard and Romelu Lukaku all getting a start up front for Roberto Martinez's side. The team is less experienced going back, with Celtic center back stepping in for injured Jan Vertonghen and Monaco youngster Youri Tieleman getting his seventh international cap in the midfield.
Mexico starting XI: Guillermo Ochoa; Carlos Salcedo, Nestor Araujo, Hector Moreno, Miguel Layun; Diego Reyes, Andres Guardado (c), Carlos Vela, Hector Herrera, Hirving Lozano; Javier "Chicharito" Hernandez
Belgium starting XI: Thibaut Courtois; Thomas Meunier, Laurent Ciman, Dedryck Boyata, Thomas Vermaelen; Axel Witsel, Youri Tielemans, Nacer Chadli; Kevin De Bruyne, Eden Hazard (c), Romelu Lukaku