The Phobians fell 1-0 at Berekum Chelsea on Sunday, leaving their season summary at 3-3-3. Expectedly, the eighth-placed side are targeting a return to winning ways when they host Bechem United at the Accra Sports Stadium.
Second-placed Aduana Stars, with a game in hand, face Liberty Professionals, who picked a point from Sunday's trip to Elmina Sharks, at the Carl Reindorf Park in Dansoman.
Wafa broke into the top three for the first time this season on Sunday, and face an uphill task to protect their status. The Academy Boys are, nonetheless, tipped for full points at the expense of 2014-15 champions Ashanti Gold, owing to their impressive home record.
It will be the clash of the new boys when bottom-placed Bolga All Stars welcome sixth-positioned Elmina Sharks to the Utrecht Academy Pak in Tamale.
At the El-Wak Stadium, referee Dally Gagba will be the central man when Inter Allies lock horns with Berekum Chelsea, who sit fourth on the table.
Ebusua Dwarfs are responsible for Great Olympics' first season win last weekend and the Crabs will hope to make amends when they host Tema Youth in Cape Coast.
Oly, however, will not be in mid-week action due to the delayed arrival of scheduled opponents Wa All Stars from the Wafu tournament in Senegal.